Miriam and John (Catherine Deneuve and David Bowie) are an elegant couple with a dark secret: they are vampires. Feeding on human blood, Miriam has lived for over 2000 years. She gave her lover the gift of eternal life and together they hunt. But John begins aging rapidly, he seeks the help of Dr. Sarah Roberts (Susan Sarandon). Miriam is immediately drawn to Sarah, desiring her as her next immortal companion…